Initiating and developing multi-national collaborations is a task- and socially-oriented, dynamic process that results in shared goals and products. The initiation of the collaboration can occur from any side, but the development process—the adoption of a shared identity with the collaboration, the transcultural learning and sharing, the tolerance of differences and the recognized benefits outweighing the limitations—must be endorsed by all sides to achieve desired outcomes. This workshop discussed strategies and techniques drawing on community based participatory research methodology, Cialdini’s Principles of Persuasion, reflective listening and cultural anthropology to identify culturally relevant practices and described lessons learned during the implementation of the CAMBIO Project – Canada and Mexico Battling Childhood Obesity and the development of the Multinational Collaboration to Increase Physical Activity in Hispanics. Participants in this workshop received classroom style training and interactive demonstrations along with small group work to master skills focused on identifying collaboration strengths and weaknesses along with areas of opportunity and threats to productivity. Specific examples came from innovations in reverse innovation, relevant technology and cultural trends.